The geographical area affected by malaria has shrunk considerably over the past 50 years, but control is becoming more difficult and gains are being eroded. Increased risk of the disease is linked with changes in land use linked to activities like road building, mining, logging and agricultural and irrigation projects, particularly in "frontier" areas like the Amazon and in South-East Asia. Other causes of its spread include global climatic change, disintegration of health services, armed conflicts and mass movements of refugees. The emergence of multi-drug resistant strains of parasite is also exacerbating the situation. Via the explosion of easy international travel, imported cases of malaria are now more frequently registered in developed countries. Malaria is re-emerging in areas where it was previously under control or eradicated e.g., in the Central Asian Republics of Tajikistan and Azerbaijan, and in Korea.
There are some significant points regarding prevalence of the disease:
Most affected are the tropical regions. It is in these areas that Plasmodium falciparum is rampant, capable of inducing pernicious malaria that can be fatal.
In Africa, malaria is widely distributed throughout the tropical regions, where a large number of areas are resistant to chloroquine, used to prevent Plasmodium falciparum. North Africa is very little affected and only by the much less dangerous Plasmodium vivax and Plasmodium malariae.
Reunion Island contains no risk of transmission. In Central and South America, important centres of chloroquine-resistant Plasmodium falciparum have developed. North America remains unaffected, as do Guadeloupe and Martinique. In Asia, Thailand, Vietnam, Cambodia and China in particular harbour the infection, with a large number of centres of resistance to chloroquine; it was here in these regions that the first resistant strains appeared.
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